Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage

5-fluorodeoxyuridine (5-FdU, floxuridine) is active against multiple cancers through the inhibition of thymidylate synthase, which consequently introduces uracil and 5-FU incorporation into the genome. Uracil DNA glycosylase (UDG) is one of the main enzymes responsible for the removal of uracil and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Yan, Yan, Han, Xiangzi, Qing, Yulan, Condie, Allison G., Gorityala, Shashank, Yang, Shuming, Xu, Yan, Zhang, Youwei, Gerson, Stanton L.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312313/
https://ncbi.nlm.nih.gov/pubmed/27517750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11151
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