Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons

The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been reported to participate in the prevalent NMDAR subtype at synapses, the GluN1/2A...

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Pubblicato in:Oncotarget
Autori principali: Ramos-Fernández, Eva, Tajes, Marta, ILL-Raga, Gerard, Vargas, Lina, Busquets-García, Arnau, Bosch-Morató, Mònica, Guivernau, Biuse, Valls-Comamala, Victòria, Gomis, Maria, Grau, Cristina, Fandos, César, Rosen, Mark D., Rabinowitz, Michael H., Inestrosa, Nibaldo, Maldonado, Rafael, Altafaj, Xavier, Ozaita, Andrés, Alvarez, Alejandra, Vicente, Rubén, Valverde, Miguel A., Muñoz, Francisco J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper: Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312282/
https://ncbi.nlm.nih.gov/pubmed/27557499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11417
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