Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons

The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been reported to participate in the prevalent NMDAR subtype at synapses, the GluN1/2A...

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Publicado en:Oncotarget
Autores principales: Ramos-Fernández, Eva, Tajes, Marta, ILL-Raga, Gerard, Vargas, Lina, Busquets-García, Arnau, Bosch-Morató, Mònica, Guivernau, Biuse, Valls-Comamala, Victòria, Gomis, Maria, Grau, Cristina, Fandos, César, Rosen, Mark D., Rabinowitz, Michael H., Inestrosa, Nibaldo, Maldonado, Rafael, Altafaj, Xavier, Ozaita, Andrés, Alvarez, Alejandra, Vicente, Rubén, Valverde, Miguel A., Muñoz, Francisco J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312282/
https://ncbi.nlm.nih.gov/pubmed/27557499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11417
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