HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, in part, due to resistance to both conventional and targeted therapeutics. Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) directly induces apoptosis through engagement of cell surface Death Receptors (DR4 and...

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Bibliografske podrobnosti
izdano v:Mol Cancer Res
Main Authors: Romeo, Carmella, Weber, Matthew C., Zarei, Mahsa, DeCicco, Danielle, Chand, Saswati N., Lobo, Angie D., Winter, Jordan M., Sawicki, Janet A., Sachs, Jonathan N., Meisner-Kober, Nicole, Yeo, Charles J., Vadigepalli, Rajanikanth, Tykocinski, Mark L., Brody, Jonathan R.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312260/
https://ncbi.nlm.nih.gov/pubmed/27053682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0448
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