PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons

We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency. The cognate enzyme, PC1/3, processes many prohormones in neuroe...

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Détails bibliographiques
Publié dans:Stem Cell Reports
Auteurs principaux: Wang, Liheng, Sui, Lina, Panigrahi, Sunil K., Meece, Kana, Xin, Yurong, Kim, Jinrang, Gromada, Jesper, Doege, Claudia A., Wardlaw, Sharon L., Egli, Dieter, Leibel, Rudolph L.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312251/
https://ncbi.nlm.nih.gov/pubmed/28132887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.12.021
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