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CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses

CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target. However the success of the therapeutic targeting of CXCR2 is threatened by o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dyer, Douglas P., Pallas, Kenneth, Ruiz, Laura Medina, Schuette, Fabian, Wilson, Gillian J., Graham, Gerard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311995/
https://ncbi.nlm.nih.gov/pubmed/28205614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42681
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