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GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice

BACKGROUND: Deficiency of membrane G-protein coupled receptor (GPCR) kinase-5 (GRK5) recently has been linked to early AD pathogenesis, and has been suggested to contribute to augmented microglial activation in vitro by sensitizing relevant GPCRs. However, GRK5 deficient mice did not show any signs...

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Bibliografiske detaljer
Main Authors: Li, Longxuan, Liu, Jun, Suo, William Z
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442054/
https://ncbi.nlm.nih.gov/pubmed/18522748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-24
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