GRK5 Deficiency Leads to Reduced Hippocampal Acetylcholine Level via Impaired Presynaptic M2/M4 Autoreceptor Desensitization

G protein-coupled receptor kinase 5 (GRK5) deficiency has been linked recently to early Alzheimer disease (AD), but the mechanism by which GRK5 deficiency may contribute to AD pathogenesis remains elusive. Here we report that overexpression of dominant negative mutant of GRK5 (dnGRK5) in a cholinerg...

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Detalhes bibliográficos
Main Authors: Liu, Jun, Rasul, Imtiaz, Sun, Yuning, Wu, Guisheng, Li, Longxuan, Premont, Richard T., Suo, William Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740582/
https://ncbi.nlm.nih.gov/pubmed/19478075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005959
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