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Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively
Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3′-5′ exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a...
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| Udgivet i: | RNA |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5311490/ https://ncbi.nlm.nih.gov/pubmed/27881476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.059196.116 |
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