Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

The transient receptor potential channels (TRPs) respond to chemical irritants and temperature. TRPV1 responds to the itch-inducing endogenous signal histamine, and TRPA1 responds to the itch-inducing chemical chloroquine. We showed that, in sensory neurons, TRPV4 is important for both chloroquine-a...

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Udgivet i:Sci Signal
Main Authors: Kim, Seungil, Barry, Devin M., Liu, Xian-Yu, Yin, Shijin, Munanairi, Admire, Meng, Qing-Tao, Cheng, Wei, Mo, Ping, Wan, Li, Liu, Shen-Bin, Ratnayake, Kasun, Zhao, Zhong-Qiu, Gautam, Narasimhan, Zheng, Jie, Ajith Karunarathne, W. K., Chen, Zhou-Feng
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310287/
https://ncbi.nlm.nih.gov/pubmed/27436359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf1047
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