Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations

The transient receptor potential channels (TRPs) respond to chemical irritants and temperature. TRPV1 responds to the itch-inducing endogenous signal histamine, and TRPA1 responds to the itch-inducing chemical chloroquine. We showed that, in sensory neurons, TRPV4 is important for both chloroquine-a...

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Publicado no:Sci Signal
Main Authors: Kim, Seungil, Barry, Devin M., Liu, Xian-Yu, Yin, Shijin, Munanairi, Admire, Meng, Qing-Tao, Cheng, Wei, Mo, Ping, Wan, Li, Liu, Shen-Bin, Ratnayake, Kasun, Zhao, Zhong-Qiu, Gautam, Narasimhan, Zheng, Jie, Ajith Karunarathne, W. K., Chen, Zhou-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310287/
https://ncbi.nlm.nih.gov/pubmed/27436359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf1047
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