Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice

Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRP...

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Pubblicato in:Cell Rep
Autori principali: Munanairi, Admire, Liu, Xian-Yu, Barry, Devin M., Yang, Qianyi, Yin, Jun-Bin, Jin, Hua, Li, Hui, Meng, Qing-Tao, Peng, Jia-Hang, Wu, Zhen-Yu, Yin, Jun, Zhou, Xuan-Yi, Wan, Li, Mo, Ping, Kim, Seungil, Huo, Fu-Quan, Jeffry, Joseph, Li, Yun-Qing, Bardoni, Rita, Bruchas, Michael R., Chen, Zhou-Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937707/
https://ncbi.nlm.nih.gov/pubmed/29669290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.087
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