Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus

It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that a...

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Vydáno v:J Virol
Hlavní autoři: To, Janet, Surya, Wahyu, Fung, To Sing, Li, Yan, Verdià-Bàguena, Carmina, Queralt-Martin, Maria, Aguilella, Vicente M., Liu, Ding Xiang, Torres, Jaume
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309962/
https://ncbi.nlm.nih.gov/pubmed/27974570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02158-16
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