Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus

It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that a...

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Bibliographic Details
Published in:J Virol
Main Authors: To, Janet, Surya, Wahyu, Fung, To Sing, Li, Yan, Verdià-Bàguena, Carmina, Queralt-Martin, Maria, Aguilella, Vicente M., Liu, Ding Xiang, Torres, Jaume
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309962/
https://ncbi.nlm.nih.gov/pubmed/27974570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02158-16
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