Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus

It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that a...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: To, Janet, Surya, Wahyu, Fung, To Sing, Li, Yan, Verdià-Bàguena, Carmina, Queralt-Martin, Maria, Aguilella, Vicente M., Liu, Ding Xiang, Torres, Jaume
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Structure and Assembly
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309962/
https://ncbi.nlm.nih.gov/pubmed/27974570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02158-16
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