Inhibition of the Human Respiratory Syncytial Virus Small Hydrophobic Protein and Structural Variations in a Bicelle Environment

The small hydrophobic (SH) protein is a 64-amino-acid polypeptide encoded by the human respiratory syncytial virus (hRSV). SH protein has a single α-helical transmembrane (TM) domain that forms pentameric ion channels. Herein, we report the first inhibitor of the SH protein channel, pyronin B, and w...

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Detalhes bibliográficos
Main Authors: Li, Yan, To, Janet, Verdià-Baguena, Carmina, Dossena, Silvia, Surya, Wahyu, Huang, Mei, Paulmichl, Markus, Liu, Ding Xiang, Aguilella, Vicente M., Torres, Jaume
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178740/
https://ncbi.nlm.nih.gov/pubmed/25100835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00839-14
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