Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression

Local interactions between cancer cells and stroma can produce systemic effects on distant organs to govern cancer progression. Here we show that IGF2 secreted by inhibitor of differentiation (Id1)-overexpressing oesophageal cancer cells instigates VEGFR1-positive bone marrow cells in the tumour mac...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xu, Wen Wen, Li, Bin, Guan, Xin Yuan, Chung, Sookja K., Wang, Yang, Yip, Yim Ling, Law, Simon Y. K., Chan, Kin Tak, Lee, Nikki P. Y., Chan, Kwok Wah, Xu, Li Yan, Li, En Min, Tsao, Sai Wah, He, Qing-Yu, Cheung, Annie L. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309924/
https://ncbi.nlm.nih.gov/pubmed/28186102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14399
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