Extremely stringent activation of p16(INK4a) prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression

Cervical epithelial cell immortalization with defined genetic factors without viral oncogenes has never been reported. Here we report that HPV-negative cervical epithelial cells failed to be immortalized by telomerase activation or the combination of p53 knockdown and telomerase activation. Under th...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Hang, Su, Tiwari, Agnes F.Y., Ngan, Hextan Y.S., Yip, Yim-Ling, Cheung, Annie L.M., Tsao, Sai Wah, Deng, Wen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216750/
https://ncbi.nlm.nih.gov/pubmed/27344169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10120
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