Identification of the discontinuous binding site in human interleukin 1 beta for the type I interleukin 1 receptor.

Human interleukin 1 beta (IL-1 beta) exerts its diverse biological effects by binding to specific receptors on target cells. Two types of IL-1 receptor (IL-1R) have been identified: the type I IL-1R (p80) and the type II IL-1R (p68). Using site-specific mutagenesis, we have identified the binding si...

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Main Authors: Labriola-Tompkins, E, Chandran, C, Kaffka, K L, Biondi, D, Graves, B J, Hatada, M, Madison, V S, Karas, J, Kilian, P L, Ju, G
Format: Artigo
Sprog:Inglês
Udgivet: 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC53098/
https://ncbi.nlm.nih.gov/pubmed/1837145
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