N‐Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs

KEY POINTS: Intrauterine growth restriction (IUGR) is associated with vascular dysfunction, oxidative stress and signs of endothelial epigenetic programming of the umbilical vessels. There is no evidence that this epigenetic programming is occurring on systemic fetal arteries. In IUGR guinea pigs we...

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Veröffentlicht in:J Physiol
Hauptverfasser: Herrera, Emilio A., Cifuentes‐Zúñiga, Francisca, Figueroa, Esteban, Villanueva, Cristian, Hernández, Cherie, Alegría, René, Arroyo‐Jousse, Viviana, Peñaloza, Estefania, Farías, Marcelo, Uauy, Ricardo, Casanello, Paola, Krause, Bernardo J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309367/
https://ncbi.nlm.nih.gov/pubmed/27739590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273396
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