Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition

Chronic intermittent hypoxia (CIH), the main attribute of obstructive sleep apnea (OSA), produces oxidative stress, endothelial dysfunction, and hypertension. Nitric oxide (NO) plays a critical role in controlling the vasomotor tone. The NO level depends on the L-arginine level, which can be reduced...

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Publicat a:Front Physiol
Autors principals: Krause, Bernardo J., Casanello, Paola, Dias, Ana C., Arias, Paulina, Velarde, Victoria, Arenas, German A., Preite, Marcelo D., Iturriaga, Rodrigo
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066978/
https://ncbi.nlm.nih.gov/pubmed/30087615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00901
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