In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms

Balancing surface functionalization and low immune recognition of nanomedicines is a major challenge. Opsonization with the third component of the complement protein (C3) plays a major role in immune cell recognition of nanomedicines. We used dextran-coated superparamagnetic iron oxide nanoworms (SP...

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Publicado no:Front Immunol
Main Authors: Wang, Guankui, Griffin, James I., Inturi, Swetha, Brenneman, Barbara, Banda, Nirmal K., Holers, V. Michael, Moghimi, Seyed Moein, Simberg, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309246/
https://ncbi.nlm.nih.gov/pubmed/28239384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00151
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