Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice

NUCKS1 is a 27 kD vertebrate-specific protein, with a role in the DNA damage response. Here, we show that after 4 Gy total-body X-irradiation, Trp53+/− Nucks1+/− mice more rapidly developed tumors, particularly thymic lymphoma (TL), than Trp53+/− mice. TLs in both cohorts showed loss of heterozygosi...

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Publicado en:Oncotarget
Autores principales: Yue, Yangbo, Leung, Stanley G., Liu, Yueyong, Huang, Yurong, Grundt, Kirsten, Østvold, Anne-Carine, Jen, Kuang-Yu, Schild, David, Mao, Jian-Hua, Wiese, Claudia
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308697/
https://ncbi.nlm.nih.gov/pubmed/27542204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11297
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