Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair

UVB exposure leads to DNA damage, which when unrepaired induces C>T transitions. These mutations are found throughout the melanoma genome, particularly in non-transcribed regions. The global genome repair (GGR) branch of nucleotide excision repair (NER) is responsible for repairing UV-induced DNA...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Budden, Timothy, Davey, Ryan J., Vilain, Ricardo E., Ashton, Katie A., Braye, Stephen G., Beveridge, Natalie J., Bowden, Nikola A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308628/
https://ncbi.nlm.nih.gov/pubmed/27487145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10902
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