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A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva

Sensors employing split aptamers that reassemble in the presence of a target can achieve excellent specificity, but the accompanying reduction of target affinity mitigates any overall gains in sensitivity. We for the first time have developed a split aptamer that achieves enhanced target-binding aff...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Yu, Haixiang, Canoura, Juan, Guntupalli, Bhargav, Lou, Xinhui, Xiao, Yi
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308383/
https://ncbi.nlm.nih.gov/pubmed/28451157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc01833e
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