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Sensitive Detection of Small-Molecule Targets Using Cooperative Binding Split Aptamers and Enzyme-Assisted Target Recycling

Signal amplification via enzyme-assisted target recycling (EATR) offers a powerful means for improving the sensitivity of DNA detection assays, but it has proven challenging to employ EATR with aptamer-based assays for small-molecule detection due to insensitive target response of aptamers. Here, we...

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Vydáno v:Anal Chem
Hlavní autoři: Yu, Haixiang, Canoura, Juan, Guntupalli, Bhargav, Alkhamis, Obtin, Xiao, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803384/
https://ncbi.nlm.nih.gov/pubmed/29294287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03625
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