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Nickel pincer model of the active site of lactate racemase involves ligand participation in hydride transfer

Lactate racemase is the first enzyme known to possess a metal pincer active site. The enzyme interconverts d- and l-lactic acid, which is important for the assembly of cell walls in many microorganisms. Here, we report a synthetic model of the active site of lactate racemase, which features a pyridi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Xu, Tao, Wodrich, Matthew D., Scopelliti, Rosario, Corminboeuf, Clemence, Hu, Xile
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307482/
https://ncbi.nlm.nih.gov/pubmed/28115700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616038114
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