Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase domain-like protein (MLKL), which results in disruption of the plasma membrane. Necroptotic cell lysis, and resultant release of proinflammatory me...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Conos, Stephanie A., Chen, Kaiwen W., De Nardo, Dominic, Hara, Hideki, Whitehead, Lachlan, Núñez, Gabriel, Masters, Seth L., Murphy, James M., Schroder, Kate, Vaux, David L., Lawlor, Kate E., Lindqvist, Lisa M., Vince, James E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307433/
https://ncbi.nlm.nih.gov/pubmed/28096356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613305114
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