Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

ISWI-family nucleosome remodeling enzymes need the histone H4 N-terminal tail to mobilize nucleosomes. Here we mapped the H4-tail binding pocket of ISWI. Surprisingly the binding site was adjacent to but not overlapping with the docking site of an auto-regulatory motif, AutoN, in the N-terminal regi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ludwigsen, Johanna, Pfennig, Sabrina, Singh, Ashish K, Schindler, Christina, Harrer, Nadine, Forné, Ignasi, Zacharias, Martin, Mueller-Planitz, Felix
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305211/
https://ncbi.nlm.nih.gov/pubmed/28109157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21477
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