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Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail
SCF (Skp1·CUL1·F-box protein·ROC1) E3 ubiquitin ligase and Cdc34 E2-conjugating enzyme catalyze polyubiquitination in a precisely regulated fashion. Here, we describe biochemical evidence suggesting an autoinhibitory role played by the human CUL1 ECTD (extreme C-terminal domain; spanning the C-termi...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519045/ https://ncbi.nlm.nih.gov/pubmed/18723677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806155105 |
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