M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord.

The 20-amino acid peptide M-15 binds with high affinity (IC50 approximately 0.1 nM) to 125I-labeled galanin (125I-GAL) binding sites in membranes from the ventral hippocampus, midbrain, and rat spinal cord. Receptor autoradiographic studies show that M-15 can displace 125I-GAL from all labeled sites...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bartfai, T, Bedecs, K, Land, T, Langel, U, Bertorelli, R, Girotti, P, Consolo, S, Xu, X J, Wiesenfeld-Hallin, Z, Nilsson, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53052/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1720557/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.23.10961
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