M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord.

The 20-amino acid peptide M-15 binds with high affinity (IC50 approximately 0.1 nM) to 125I-labeled galanin (125I-GAL) binding sites in membranes from the ventral hippocampus, midbrain, and rat spinal cord. Receptor autoradiographic studies show that M-15 can displace 125I-GAL from all labeled sites...

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Autores principales: Bartfai, T, Bedecs, K, Land, T, Langel, U, Bertorelli, R, Girotti, P, Consolo, S, Xu, X J, Wiesenfeld-Hallin, Z, Nilsson, S
Formato: Artigo
Lenguaje:Inglês
Publicado: 1991
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC53052/
https://ncbi.nlm.nih.gov/pubmed/1720557
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