Transient Dysregulation of Dopamine Signaling in a Developing Drosophila Arousal Circuit Permanently Impairs Behavioral Responsiveness in Adults

The dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. To test this hypothesis in a high-throughput animal model, we have transiently manipulated dopamine sig...

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Detalhes bibliográficos
Publicado no:Front Psychiatry
Main Authors: Ferguson, Lachlan, Petty, Alice, Rohrscheib, Chelsie, Troup, Michael, Kirszenblat, Leonie, Eyles, Darryl W., van Swinderen, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Psychiatry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304146/
https://ncbi.nlm.nih.gov/pubmed/28243212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpsyt.2017.00022
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