Transient Dysregulation of Dopamine Signaling in a Developing Drosophila Arousal Circuit Permanently Impairs Behavioral Responsiveness in Adults

The dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. To test this hypothesis in a high-throughput animal model, we have transiently manipulated dopamine sig...

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Pubblicato in:Front Psychiatry
Autori principali: Ferguson, Lachlan, Petty, Alice, Rohrscheib, Chelsie, Troup, Michael, Kirszenblat, Leonie, Eyles, Darryl W., van Swinderen, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Psychiatry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304146/
https://ncbi.nlm.nih.gov/pubmed/28243212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpsyt.2017.00022
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