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Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

Draper/Ced-1/MEGF-10 is an engulfment receptor that promotes clearance of cellular debris in C. elegans, Drosophila and mammals. Draper signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrangements and target engulfment through Rac1. Glia also alter gene...

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Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Lu, Tsai-Yi, MacDonald, Jennifer M., Neukomm, Lukas J., Sheehan, Amy E., Bradshaw, Rachel, Logan, Mary A., Freeman, Marc R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303877/
https://ncbi.nlm.nih.gov/pubmed/28165006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14355
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