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Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

Advanced age is the greatest risk factor for neurodegenerative disorders, but the mechanisms that render the senescent brain vulnerable to disease are unclear. Glial immune responses provide neuroprotection in a variety of contexts. Thus, we explored how glial responses to neurodegeneration are alte...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Purice, Maria D., Speese, Sean D., Logan, Mary A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034330/
https://ncbi.nlm.nih.gov/pubmed/27647497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12871
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