GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers

During the process of tumorigenesis, inactivation of tumor suppressors is a critical step. EZH2, a histone methyltransferase, promotes cell growth and migration through catalyzing trimethylation of histone H3 at Lys 27 (H3K27me3) and plays an important role in tumorigenesis. Its expression can be co...

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Vydáno v:Oncotarget
Hlavní autoři: Ko, How-Wen, Lee, Heng-Huan, Huo, Longfei, Xia, Weiya, Yang, Cheng-Chieh, Hsu, Jennifer L., Li, Long-Yuan, Lai, Chien-Chen, Chan, Li-Chuan, Cheng, Chien-Chia, Labaff, Adam M., Liao, Hsin-Wei, Lim, Seung-Oe, Li, Chia-Wei, Wei, Yongkun, Nie, Lei, Yamaguchi, Hirohito, Hung, Mien-Chie
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302978/
https://ncbi.nlm.nih.gov/pubmed/27494834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11008
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