CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonst...

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Bibliografiske detaljer
Main Authors: Wei, Yongkun, Chen, Ya-Huey, Li, Long-Yuan, Lang, Jingyu, Yeh, Su-Peng, Shi, Bin, Yang, Cheng-Chieh, Yang, Jer-Yen, Lin, Chun-Yi, Lai, Chien-Chen, Hung, Mien-Chie
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076036/
https://ncbi.nlm.nih.gov/pubmed/21131960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2139
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