CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

Triple-negative breast cancer (TNBC), which lacks estrogen receptor α (ERα), progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression, is closely related to basal-like breast cancer. Previously, we and others report that cyclin E/cyclin-dependent kinase 2 (CDK2) phosphor...

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Publicat a:Nat Commun
Autors principals: Nie, Lei, Wei, Yongkun, Zhang, Fei, Hsu, Yi-Hsin, Chan, Li-Chuan, Xia, Weiya, Ke, Baozhen, Zhu, Cihui, Deng, Rong, Tang, Jun, Yao, Jun, Chu, Yu-Yi, Zhao, Xixi, Han, Ye, Hou, Junwei, Huo, Longfei, Ko, How-Wen, Lin, Wan-Chi, Yamaguchi, Hirohito, Hsu, Jung-Mao, Yang, Yi, Pan, Dean N., Hsu, Jennifer L., Kleer, Celina G., Davidson, Nancy E., Hortobagyi, Gabriel N., Hung, Mien-Chie
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6841924/
https://ncbi.nlm.nih.gov/pubmed/31704972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13105-5
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