EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer

Inhibitors against poly (ADP-ribose) polymerase (PARP) are promising targeted agents currently used to treat BRCA-mutant ovarian cancer and are in clinical trials for other cancer types, including BRCA-mutant breast cancer. To enhance the clinical response to PARP inhibitors (PARPi), understanding t...

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Udgivet i:Oncogene
Main Authors: Yamaguchi, Hirohito, Du, Yi, Nakai, Katsuya, Ding, Ming, Chang, Shih-Shin, Hsu, Jennifer L., Yao, Jun, Wei, Yongkun, Nie, Lei, Jiao, Shiping, Chang, Wei-Chao, Chen, Chung-Hsuan, Yu, Yonghao, Hortobagyi, Gabriel N., Hung, Mien-Chie
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786281/
https://ncbi.nlm.nih.gov/pubmed/28925391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.311
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