Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells

p66Shc attenuates mitogenic, prosurvival and chemotactic signaling and promotes apoptosis in lymphocytes. Consistently, p66Shc deficiency contributes to the survival and trafficking abnormalities of chronic lymphocytic leukemia (CLL) B cells. The mechanism of p66shc silencing in CLL B cells is methy...

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Vydáno v:Oncotarget
Hlavní autoři: Cattaneo, Francesca, Patrussi, Laura, Capitani, Nagaja, Frezzato, Federica, D'Elios, Mario Milco, Trentin, Livio, Semenzato, Gianpietro, Baldari, Cosima T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302975/
https://ncbi.nlm.nih.gov/pubmed/27494881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10977
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