p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape

The Shc family adaptor p66Shc acts as a negative regulator of proliferative and survival signals triggered by the B-cell receptor and, by enhancing the production of reactive oxygen species, promotes oxidative stress-dependent apoptosis. Additionally, p66Shc controls the expression and function of c...

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Pubblicato in:Haematologica
Autori principali: Patrussi, Laura, Capitani, Nagaja, Ulivieri, Cristina, Manganaro, Noemi, Granai, Massimo, Cattaneo, Francesca, Kabanova, Anna, Mundo, Lucia, Gobessi, Stefania, Frezzato, Federica, Visentin, Andrea, Finetti, Francesca, Pelicci, Pier Giuseppe, D’Elios, Mario M., Trentin, Livio, Semenzato, Gianpietro, Leoncini, Lorenzo, Efremov, Dimitar G., Baldari, Cosima T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886430/
https://ncbi.nlm.nih.gov/pubmed/30819907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.209981
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