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HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance

Decreased expression of NKG2D ligands on HBV-infected human hepatoma cells impairs NK cells lysis. However, which components of HBV exert this effect and the precise mechanisms need to be further investigated. In the present study, we observed that the HBx and HBc genes significantly down-regulated...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guan, Yun, Li, Weiqun, Hou, Zhaohua, Han, Qiuju, Lan, Peixiang, Zhang, Jian, Tian, Zhigang, Zhang, Cai
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302899/
https://ncbi.nlm.nih.gov/pubmed/27528231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11271
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