Cooperative binding of transcription factors orchestrates reprogramming

Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To gain a mechanistic understanding of their function, we mapped OSKM-binding, stage-specific transcription-factors (TFs), and chromatin-states in discrete reprogramming stages and performed loss- and gain-of-function experim...

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Bibliografische gegevens
Gepubliceerd in:Cell
Hoofdauteurs: Chronis, Constantinos, Fiziev, Petko, Papp, Bernadett, Butz, Stefan, Bonora, Giancarlo, Sabri, Shan, Ernst, Jason, Plath, Kathrin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302508/
https://ncbi.nlm.nih.gov/pubmed/28111071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.016
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