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Cooperative binding of transcription factors orchestrates reprogramming
Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To gain a mechanistic understanding of their function, we mapped OSKM-binding, stage-specific transcription-factors (TFs), and chromatin-states in discrete reprogramming stages and performed loss- and gain-of-function experim...
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| Publicat a: | Cell |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5302508/ https://ncbi.nlm.nih.gov/pubmed/28111071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.016 |
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