P2X7 Receptor Mediates Spinal Microglia Activation of Visceral Hyperalgesia in a Rat Model of Chronic Pancreatitis

BACKGROUND & AIMS: Molecular mechanisms underlying the activated spinal microglia in association with the pain in chronic pancreatitis (CP) remain unknown. We tested whether P2X7R on spinal microglia mediates the pathogenesis of visceral pain using a CP rat model. METHODS: The CP model was induc...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Liu, Pei-Yi, Lee, I-Hui, Tan, Ping-Heng, Wang, Yen-Po, Tsai, Chia-Fen, Lin, Han-Chieh, Lee, Fa-Yauh, Lu, Ching-Liang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301503/
https://ncbi.nlm.nih.gov/pubmed/28210704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.07.008
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