P2X7 Receptor Mediates Spinal Microglia Activation of Visceral Hyperalgesia in a Rat Model of Chronic Pancreatitis

BACKGROUND & AIMS: Molecular mechanisms underlying the activated spinal microglia in association with the pain in chronic pancreatitis (CP) remain unknown. We tested whether P2X7R on spinal microglia mediates the pathogenesis of visceral pain using a CP rat model. METHODS: The CP model was induc...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Liu, Pei-Yi, Lee, I-Hui, Tan, Ping-Heng, Wang, Yen-Po, Tsai, Chia-Fen, Lin, Han-Chieh, Lee, Fa-Yauh, Lu, Ching-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301503/
https://ncbi.nlm.nih.gov/pubmed/28210704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.07.008
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