Valproic Acid Attenuates Microgliosis in Injured Spinal Cord and Purinergic P2X(4) Receptor Expression in Activated Microglia

Peripheral injection with a high dose of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, into animals with mild or moderate spinal cord injury (SCI) for 1 week can reduce spinal cord tissue loss and promote hindlimb locomotor recovery. A purinergic adenosine triphosphate (ATP) receptor...

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Pubblicato in:J Neurosci Res
Autori principali: Lu, Wen-Hsin, Wang, Chih-Yen, Chen, Po-See, Wang, Jing-Wen, Chuang, De-Maw, Yang, Chung-Shi, Tzeng, Shun-Fen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322559/
https://ncbi.nlm.nih.gov/pubmed/23404572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.23200
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