Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization

The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we in...

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Udgivet i:Sci Rep
Main Authors: Shi, Ying, Lai, Xiangru, Ye, Lingyan, Chen, Keqiang, Cao, Zheng, Gong, Wanghua, Jin, Lili, Wang, Chunyan, Liu, Mingyong, Liao, Yuan, Wang, Ji Ming, Zhou, Naiming
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301212/
https://ncbi.nlm.nih.gov/pubmed/28186140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42279
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