Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock

Inflammation and cellular energetics play critical roles in organ dysfunction following hemorrhagic shock. Recent studies suggest a putative role for sirtuin 1 (SIRT1) in potentiating mitochondrial function and improving organ function following hemorrhagic shock in animal models. SIRT1 is an NAD+ d...

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Bibliografiske detaljer
Udgivet i:Biochim Biophys Acta Mol Basis Dis
Main Authors: Subramani, Kumar, Chu, Xiaogang, Warren, Marie, Lee, Mariah, Lu, Sumin, Singh, Nagendra, Raju, Raghavan
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353685/
https://ncbi.nlm.nih.gov/pubmed/30625381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.01.009
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