Optical Trapping Nanometry of Hypermethylated CPG-Island DNA

Cytosine methylation is a key mechanism of epigenetic regulation. CpG-dense loci, called “CpG islands”, play a particularly important role in modulating gene expression. Methylation has long been suspected to alter the physical properties of DNA, but the full spectrum of the evoked changes is unknow...

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Bibliographic Details
Published in:Biophys J
Main Authors: Pongor, Csaba I., Bianco, Pasquale, Ferenczy, György, Kellermayer, Richárd, Kellermayer, Miklós
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2017
Subjects:
Nucleic Acids and Genome Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300791/
https://ncbi.nlm.nih.gov/pubmed/28109529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.12.029
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