Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

Protein kinase A (PKA) plays critical roles in neuronal function that are mediated by different regulatory (R) subunits. Deficiency in either the RIβ or the RIIβ subunit results in distinct neuronal phenotypes. Although RIβ contributes to synaptic plasticity, it is the least studied isoform. Using i...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ilouz, Ronit, Lev-Ram, Varda, Bushong, Eric A, Stiles, Travis L, Friedmann-Morvinski, Dinorah, Douglas, Christopher, Goldberg, Jeffrey L, Ellisman, Mark H, Taylor, Susan S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300705/
https://ncbi.nlm.nih.gov/pubmed/28079521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17681
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