High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila

Genomic sequencing has implicated large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system is needed to validate gene associations with pathology. We developed a Drosophila-based functional system to screen candidate disease genes identif...

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Udgivet i:eLife
Main Authors: Zhu, Jun-yi, Fu, Yulong, Nettleton, Margaret, Richman, Adam, Han, Zhe
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Developmental Biology and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300701/
https://ncbi.nlm.nih.gov/pubmed/28084990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22617
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